Type IV Secretion in Gram-Negative and Gram-Positive Bacteria by Steffen Backert & Elisabeth Grohmann

Author:Steffen Backert & Elisabeth Grohmann
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

2 Components of the Agrobacterium tumefaciens T4SS

Despite their functional diversity, the protein composition of many T4SS is similar to the VirB/VirD4 system from A. tumefaciens that is composed of 12 components (Fig. 1) discussed individually in the following. The T4SS components can be divided into three groups, the cytoplasmic ATPases (VirB4, VirB11, and VirD4) that provide energy for T4SS assembly and/or substrate translocation, the surface-exposed pilus components (VirB2 and VirB5), and the periplasmic core components (VirB1, VirB3, VirB6, VirB7, VirB8, VirB9, and VirB10). These proteins are individually described in more detail in the following.

Fig. 1Overview of the T-DNA transfer process and localization of the components of the A. tumefaciens VirB/D4 T4SS in the bacterial cell envelope. a Schematic overview of the process of T-DNA transfer from A. tumefaciens. This organism has a bipartite chromosome and it carries the Ti-plasmid from which a piece of T-DNA is excised by VirD2, and the T-complex (T-DNA plus VirD2) is translocated into plant cells via the T4SS. b The T4SS components can be divided into three groups, the cytoplasmic ATPases (VirB4, VirB11, and VirD4, in orange color), the surface-exposed pilus components (VirB2 and VirB5, in green color), and the periplasmic core components (VirB1, VirB3, VirB6, VirB7, VirB8, VirB9, and VirB10, in blue color)

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